Technology Process of (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 4-aminobutyl sulfide
There total 8 articles about (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 4-aminobutyl sulfide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 24h;
Ambient temperature;
DOI:10.1021/jm00384a026
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 99 percent / NaH, EtSH / dimethylformamide / 19 h / 120 °C
2: 89 percent / imidazole / dimethylformamide / 1 h
3: diethyl ether; hexane / 20 h / Ambient temperature
4: 1.) BH3*THF, 2.) H2O, NaOH, H2O2 / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h
5: 76 percent / Ph3P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C
6: 58 percent / LiAlH4 / diethyl ether / 0.08 h / 0 °C
7: 90 percent / KH / tetrahydrofuran / 1.25 h / -78 - 20 °C
8: 68 percent / LiAlH4 / tetrahydrofuran / 24 h / Ambient temperature
With
1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; potassium hydride; sodium hydride; triphenylphosphine; ethanethiol;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 89 percent / imidazole / dimethylformamide / 1 h
2: diethyl ether; hexane / 20 h / Ambient temperature
3: 1.) BH3*THF, 2.) H2O, NaOH, H2O2 / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h
4: 76 percent / Ph3P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C
5: 58 percent / LiAlH4 / diethyl ether / 0.08 h / 0 °C
6: 90 percent / KH / tetrahydrofuran / 1.25 h / -78 - 20 °C
7: 68 percent / LiAlH4 / tetrahydrofuran / 24 h / Ambient temperature
With
1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; potassium hydride; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026
