N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂)

Base Information

• Chemical Name: N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂)
• CAS No.: 1384445-22-0
• Molecular Formula: C₂₇H₂₄F₂N₄O₃S
• Molecular Weight: 524.559

Synonyms:N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂)

Chemical Property of N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂)

Chemical Property:

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Technology Process of N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂)

There total 9 articles about N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D₂) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(quinoline-8-sulfonamido)benzoic acid (116834-64-1) + C11H12(2)H2F2N2*ClH (1384448-26-3) → N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D2) (1384445-22-0)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;

Reference yield:

quinoline-8-sulfonyl chloride (18704-37-5) → N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D2) (1384445-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N-(4-(4-(3,5-difluorobenzyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide-(D2) (1384445-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

quinoline-8-sulfonyl chloride

p-aminoethylbenzoate

4-amino-benzoic acid

ethyl 4-(quinoline-8-sulfonamido)benzoate

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