6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

Base Information

Chemical Name:6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester
CAS No.:301684-03-7
Molecular Formula:C₃₁H₂₇N₃O₄
Molecular Weight:505.573
Hs Code.:

6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-<i>N</i>-isobutyl-isophthalamic acid methyl ester

Synonyms:6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

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Chemical Property of 6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

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Technology Process of 6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

There total 4 articles about 6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: N-isobutyl-6-trimethylstannanyl-isophthalamic acid methyl ester

: 301684-00-4
3-iodo-naphthalene-2-carboxylic acid (4-cyano-phenyl)-amide

: 301684-03-7
6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

Guidance literature:: With copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triphenyl-arsane; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
DOI:10.1016/S0040-4039(00)01016-9

Reference yield:

: 63212-42-0
3-iodo-2-naphthoic acid

: 301684-03-7
6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / PCl₃; 4-dimethylaminopyridine (DMAP) / xylene / 1.5 h / 150 °C

2: 55 percent / Pd₂(dba)3; Ph₃As; CuI / dimethylformamide / 6 h / 60 °C

With dmap; copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triphenyl-arsane; phosphorus trichloride; In N,N-dimethyl-formamide; xylene; 1: Condensation / 2: Stille coupling reaction;
DOI:10.1016/S0040-4039(00)01016-9

Reference yield:

: 3-Carboxy-naphthalene-2-diazonium; hydrogen sulfate

: 301684-03-7
6-[3-(4-cyano-phenylcarbamoyl)-naphthalen-2-yl]-N-isobutyl-isophthalamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: KI; H₂SO₄ / H₂O / 100 °C

2: 71 percent / PCl₃; 4-dimethylaminopyridine (DMAP) / xylene / 1.5 h / 150 °C

3: 55 percent / Pd₂(dba)3; Ph₃As; CuI / dimethylformamide / 6 h / 60 °C

With dmap; copper(l) iodide; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triphenyl-arsane; sulfuric acid; potassium iodide; phosphorus trichloride; In water; N,N-dimethyl-formamide; xylene; 1: Iodination / 2: Condensation / 3: Stille coupling reaction;
DOI:10.1016/S0040-4039(00)01016-9