Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester
CAS No.:440125-16-6
Molecular Formula:C10H18 N2 O3
Molecular Weight:214.26152
Hs Code.:
Mol file:440125-16-6.mol

Synonyms:Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester

Suppliers and Price of Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：82.35000
LogP:1.56508

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester

There total 4 articles about Carbamic acid, [(1S)-1-(cyanohydroxymethyl)propyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 151-50-8
potassium cyanide

: 153371-25-6
(2S)-2-(tert-butoxycarbonyl)aminobutyraldehyde

: 440125-16-6
1(S)-(2-cyano-1-ethyl-2-hydroxyethyl)carbamic acid tert-butyl ester

Guidance literature:: (2S)-2-(tert-butoxycarbonyl)aminobutyraldehyde; With sodium hydrogen sulfate; In 1,4-dioxane; water; at 0 ℃; for 0.166667h;

potassium cyanide; In 1,4-dioxane; water;

Reference yield:

: 34306-42-8
Boc-Abu

: 440125-16-6
1(S)-(2-cyano-1-ethyl-2-hydroxyethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / CDI, DIEA / tetrahydrofuran; dimethylformamide / Ambient temperature

2: LiAlH₄ / diethyl ether / 0.5 h / 0 - 5 °C

3: 1.) aq. NaHSO₃ / 1.) MeOH, 5 deg C, overnight, 2.) MeOH, H₂O, AcOEt, RT, 5 h

With lithium aluminium tetrahydride; sodium hydrogensulfite; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00044a013

Reference yield:

: 160801-72-9
(S)-(1-(methyloxy(methyl)amino)-1-oxobutan-2-yl)carbamate tert-butyl ester

: 440125-16-6
1(S)-(2-cyano-1-ethyl-2-hydroxyethyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 0 - 5 °C

2: 1.) aq. NaHSO₃ / 1.) MeOH, 5 deg C, overnight, 2.) MeOH, H₂O, AcOEt, RT, 5 h

With lithium aluminium tetrahydride; sodium hydrogensulfite; In diethyl ether;
DOI:10.1021/jm00044a013