Technology Process of (4S,5R)-5-[(R)-2-(4-Benzoyl-benzyloxy)-1-methyl-ethyl]-2,2,3-trimethyl-oxazolidine-4-carboxylic acid
There total 9 articles about (4S,5R)-5-[(R)-2-(4-Benzoyl-benzyloxy)-1-methyl-ethyl]-2,2,3-trimethyl-oxazolidine-4-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 92.3 percent / mCPBA / CH2Cl2 / 1.) -10 deg C, 1 h, 2.) 0 deg C, 1.5 h
2: 93 percent / Et3N / CH2Cl2 / 18 h / Ambient temperature
3: 84 percent / sodium hydride / tetrahydrofuran / 5.5 h
4: imidazole / dimethylformamide / 6 h / Ambient temperature
5: H2 / palladium hydroxide on carbon / ethanol / 1.5 h
6: KH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temp., 1 h
7: Bu4NF / tetrahydrofuran / 0.67 h / 0 °C
8: 81 percent / Jones reagent / acetone / 1 h
9: 50 percent / 2 N aq. KOH / 6 h / Heating
10: 24 h / Heating
With
1H-imidazole; potassium hydroxide; jones reagent; tetrabutyl ammonium fluoride; hydrogen; potassium hydride; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00167a026
- Guidance literature:
-
Multi-step reaction with 7 steps
1: imidazole / dimethylformamide / 6 h / Ambient temperature
2: H2 / palladium hydroxide on carbon / ethanol / 1.5 h
3: KH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temp., 1 h
4: Bu4NF / tetrahydrofuran / 0.67 h / 0 °C
5: 81 percent / Jones reagent / acetone / 1 h
6: 50 percent / 2 N aq. KOH / 6 h / Heating
7: 24 h / Heating
With
1H-imidazole; potassium hydroxide; jones reagent; tetrabutyl ammonium fluoride; hydrogen; potassium hydride;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00167a026
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 84 percent / sodium hydride / tetrahydrofuran / 5.5 h
2: imidazole / dimethylformamide / 6 h / Ambient temperature
3: H2 / palladium hydroxide on carbon / ethanol / 1.5 h
4: KH / tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temp., 1 h
5: Bu4NF / tetrahydrofuran / 0.67 h / 0 °C
6: 81 percent / Jones reagent / acetone / 1 h
7: 50 percent / 2 N aq. KOH / 6 h / Heating
8: 24 h / Heating
With
1H-imidazole; potassium hydroxide; jones reagent; tetrabutyl ammonium fluoride; hydrogen; potassium hydride; sodium hydride;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00167a026
