N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline

Base Information

Chemical Name:N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline
CAS No.:1394834-05-9
Molecular Formula:C₂₆H₂₄N₂O₃S
Molecular Weight:444.554
Hs Code.:

Synonyms:N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline

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Chemical Property of N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline

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Technology Process of N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline

There total 2 articles about N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1394833-82-9
6-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,2,3,4-tetrahydropyridine

: 622-79-7
benzyl azide

: 1394834-05-9
N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline

Guidance literature:: benzyl azide; With trifluorormethanesulfonic acid; In toluene; at 0 ℃; for 0.25h;

6-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,2,3,4-tetrahydropyridine; In toluene; at 0 - 20 ℃; for 2h;
DOI:10.1021/ol3020732

Reference yield:

: 7744-25-4
1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one

: 1394834-05-9
N-((2-(benzofuran-2-yl)-1-(phenylsulfonyl)-1,4,5,6-tetrahydropyridin-3-yl)methyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 1 h / -78 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere; Reflux

3.1: trifluorormethanesulfonic acid / toluene / 0.25 h / 0 °C

3.2: 2 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; trifluorormethanesulfonic acid; sodium hexamethyldisilazane; In tetrahydrofuran; toluene; 2.2: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol3020732