6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Base Information

Chemical Name:6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
CAS No.:1359669-08-1
Molecular Formula:C₃₀H₃₄O₅
Molecular Weight:474.597
Hs Code.:

Synonyms:6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

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Chemical Property of 6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

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Technology Process of 6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

There total 9 articles about 6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1359669-86-5
ethyl 6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 1359669-08-1
6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;
DOI:10.1021/jm2012968

Reference yield:

: 805250-50-4
4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-carbaldehyde

: 1359669-08-1
6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

With sodium tetrahydroborate; tributylphosphine; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; water; toluene; 2.1: Mitsunobu reaction;
DOI:10.1021/jm2012968

Reference yield:

: 805250-31-1
4’-hydroxy-2’,6’-dimethyl-3-biphenylcarbaldehyde

: 1359669-08-1
6-{[4'-(2-ethoxyethoxy)-2',6'-dimethylbiphenyl-3-yl]methoxy}-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

With sodium tetrahydroborate; tributylphosphine; potassium carbonate; potassium iodide; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; 3.1: Mitsunobu reaction;
DOI:10.1021/jm2012968