(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Base Information

Chemical Name:(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate
CAS No.:1246961-45-4
Molecular Formula:C₁₉H₂₆F₃NO₄
Molecular Weight:389.415
Hs Code.:

Synonyms:(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Suppliers and Price of (R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of (R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

There total 4 articles about (R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 327-52-6
1-bromo-2,4,5-trifluorobenzene

: 1246961-44-3
(S)-t-butyl 2-(2-t-butoxy-2-oxoethyl)aziridine-1-carboxylate

: 1246961-45-4
(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: 1-bromo-2,4,5-trifluorobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

(S)-t-butyl 2-(2-t-butoxy-2-oxoethyl)aziridine-1-carboxylate; With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at 0 ℃; for 6h;

Reference yield:

: 153287-86-6
(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid tert-butyl ester

: 1246961-45-4
(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 6 h / 0 °C

With di-isopropyl azodicarboxylate; isopropylmagnesium chloride; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 1676-90-0
Boc-Asp(OtBu)-OH

: 1246961-45-4
(R)-t-butyl 3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h / 0 °C

1.2: 1 h

2.1: sodium tetrahydroborate / 4 h / 0 - 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 6 h / 0 °C

With 4-methyl-morpholine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; isopropylmagnesium chloride; triphenylphosphine; In tetrahydrofuran;