(4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

Base Information

Chemical Name:(4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one
CAS No.:1134785-09-3
Molecular Formula:C₁₈H₁₄FNO₃
Molecular Weight:311.312
Hs Code.:

Synonyms:(4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

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Chemical Property of (4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

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Technology Process of (4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

There total 5 articles about (4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1134785-08-2
(R,S)-N-benzoyl-2-((2R)-1-bromopropoxy)-5-fluorophenylglycine

: 1134785-09-3
(4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

Guidance literature:: With acetic anhydride; potassium carbonate; In acetone; Ambient temperature;
DOI:10.1021/jo00392a017

Reference yield:

: 371-41-5
4-Fluorophenol

: 1134785-09-3
(4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature

2: 94 percent / LiAlH₄ / tetrahydrofuran

3: 80 percent / Br₂, triphenylphosphine / dimethylformamide / 18 h / Ambient temperature

4: 83 percent / methanesulfonic acid / 2 h

5: 90 percent / acetic anhydride, K₂CO₃ / acetone / Ambient temperature

With lithium aluminium tetrahydride; methanesulfonic acid; bromine; acetic anhydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00392a017

Reference yield:

: 103197-00-8
(R)-2-(4-fluorophenoxy)propanol

: 1134785-09-3
(4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / Br₂, triphenylphosphine / dimethylformamide / 18 h / Ambient temperature

2: 83 percent / methanesulfonic acid / 2 h

3: 90 percent / acetic anhydride, K₂CO₃ / acetone / Ambient temperature

With methanesulfonic acid; bromine; acetic anhydride; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00392a017