Technology Process of (4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one
There total 5 articles about (4R,S)-2,3-dihydro-6-fluoro-2(R)-methylspiro<4H-benzopyran-4,4'-2'-phenyloxazolidin>-5'-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
acetic anhydride; potassium carbonate;
In
acetone;
Ambient temperature;
DOI:10.1021/jo00392a017
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 72 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature
2: 94 percent / LiAlH4 / tetrahydrofuran
3: 80 percent / Br2, triphenylphosphine / dimethylformamide / 18 h / Ambient temperature
4: 83 percent / methanesulfonic acid / 2 h
5: 90 percent / acetic anhydride, K2CO3 / acetone / Ambient temperature
With
lithium aluminium tetrahydride; methanesulfonic acid; bromine; acetic anhydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00392a017
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / Br2, triphenylphosphine / dimethylformamide / 18 h / Ambient temperature
2: 83 percent / methanesulfonic acid / 2 h
3: 90 percent / acetic anhydride, K2CO3 / acetone / Ambient temperature
With
methanesulfonic acid; bromine; acetic anhydride; potassium carbonate; triphenylphosphine;
In
N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00392a017
