5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Base Information

Chemical Name:5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine
CAS No.:474103-39-4
Molecular Formula:C₃₁H₃₂Cl₃N₃OSi
Molecular Weight:597.059
Hs Code.:

5-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-<i>d</i>]pyrimidine

Synonyms:5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Suppliers and Price of 5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

There total 11 articles about 5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 474103-38-3
methanesulfonic acid 4-(tert-butyl-diphenyl-silanyloxy)-3-[4-chloro-6-(2,4-dichloro-phenylamino)-2-methyl-pyrimidin-5-yl]-butyl ester

: 474103-39-4
5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2005.05.040

Reference yield:

: (4,6-dihydroxy-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester

: 474103-39-4
5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 10 steps

1.1: 73 percent / POCl₃ / 3.5 h / Heating

2.1: 68 percent / LiHMDS / hexane; tetrahydrofuran / 0 - 20 °C

3.1: 86 percent / DIBAl-H / hexane; CH₂Cl₂ / 3 h / -78 - 0 °C

4.1: 90 percent / imidazole; DMAP / dimethylformamide / 2 h / 0 - 20 °C

5.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

5.2: 46 percent / tetrahydrofuran / 5 h / Heating

6.1: 93 percent / DMAP / CH₂Cl₂ / 48 h / 20 °C

7.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

7.2: 54 percent / NaBH₄ / CH₂Cl₂ / 3 h / 20 °C

8.1: 95 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

9.1: 100 percent / TFA / CH₂Cl₂ / 18 h / 20 °C

10.1: 48 percent / Et₃N / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydride; diisobutylaluminium hydride; ozone; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.040

Reference yield:

: 474103-23-6
2-(4,6-dichloro-2-methyl-pyrimidin-5-yl)-pent-4-en-1-ol

: 474103-39-4
5-(tert-butyl-diphenyl-silanyloxymethyl)-4-chloro-8-(2,4-dichloro-phenyl)-2-methyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / imidazole; DMAP / dimethylformamide / 2 h / 0 - 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 46 percent / tetrahydrofuran / 5 h / Heating

3.1: 93 percent / DMAP / CH₂Cl₂ / 48 h / 20 °C

4.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

4.2: 54 percent / NaBH₄ / CH₂Cl₂ / 3 h / 20 °C

5.1: 95 percent / Et₃N / CH₂Cl₂ / 18 h / 20 °C

6.1: 100 percent / TFA / CH₂Cl₂ / 18 h / 20 °C

7.1: 48 percent / Et₃N / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-imidazole; dmap; sodium hydride; ozone; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.040