D-BETA-HOMOPROLINE-HCL

Base Information

• Chemical Name: D-BETA-HOMOPROLINE-HCL
• CAS No.: 439918-59-9
• Molecular Formula: C₆H₁₁NO₂*ClH
• Molecular Weight: 165.62
• Hs Code.: 2933990090
• Mol file: 439918-59-9.mol

Synonyms:2-Pyrrolidineaceticacid, hydrochloride, (2R)- (9CI); (R)-2-(Pyrrolidin-2-yl)acetic acidhydrochloride

Chemical Property of D-BETA-HOMOPROLINE-HCL

Chemical Property:

• Melting Point: 195-197℃
• PSA: 49.33000
• LogP: 1.34390
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-2-PyrrolidineaceticacidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-2-Pyrrolidineacetic Acid Hydrochloride is the hydrochloride salf from of (R)-2-Pyrrolidineacetic Acid (P997905), a starting material for GABA inhibitors.

Technology Process of D-BETA-HOMOPROLINE-HCL

There total 1 articles about D-BETA-HOMOPROLINE-HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-pyrrolidineacetic acid hydrochloride (71985-79-0,439918-59-9,53912-85-9)

Guidance literature:

Pyrrolidin, ClCH2COONa, H2O;

DOI:10.1016/0020-1650(74)80074-7

Reference yield:

(R)-2-(pyrrolidin-2-yl)acetic acid hydrochloride salt (439918-59-9,53912-85-9) → (R)-ethyl 2-(1-(4-(2,4-dichlorobenzyloxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 3 h / 20 °C

2: caesium carbonate; palladium diacetate; johnphos / 1,4-dioxane / 16 h / 120 °C

With hydrogenchloride; palladium diacetate; caesium carbonate; johnphos; In 1,4-dioxane; water;

DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

(R)-2-(pyrrolidin-2-yl)acetic acid hydrochloride salt (439918-59-9,53912-85-9) → (R)-2-(1-(4-(2,4-dichlorobenzyloxy)phenyl)pyrrolidin-2-yl)acetic acid hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water / 3 h / 20 °C

2: caesium carbonate; palladium diacetate; johnphos / 1,4-dioxane / 16 h / 120 °C

3: sodium hydroxide / water; 1,4-dioxane / 20 °C

With hydrogenchloride; palladium diacetate; caesium carbonate; sodium hydroxide; johnphos; In 1,4-dioxane; water;

DOI:10.1021/acs.jmedchem.6b01559

Downstream raw materials:

C₁₇H₂₂N₂O₅

C₁₇H₂₂N₂O₅