1-[(2-Chlorophenyl)(phenyl)methyl]piperazine

Base Information

• Chemical Name: 1-[(2-Chlorophenyl)(phenyl)methyl]piperazine
• CAS No.: 109036-15-9
• Molecular Formula: C₁₇H₁₉ClN₂
• Molecular Weight: 286.804
• European Community (EC) Number: 825-906-0
• DSSTox Substance ID: DTXSID60412069
• Mol file: 109036-15-9.mol

Synonyms:109036-15-9;1-[(2-Chlorophenyl)phenylmethyl]piperazine;1-[(2-chlorophenyl)(phenyl)methyl]piperazine;1-[(2-chlorophenyl)-phenylmethyl]piperazine;1-((2-Chlorophenyl)(phenyl)methyl)piperazine;4997-64-2;1-(o-Chloro-alpha-phenylbenzyl)piperazine;SCHEMBL2430851;DTXSID60412069;AKOS003587206;AKOS022191312;1-(o-Chloro-|A-phenylbenzyl)piperazine;CS-0166223;FT-0664938;EN300-63955;J-002226;Z991547386;1-((2-chlorophenyl)(phenyl)methyl)piperazine? (Cetirizine Impurity

Chemical Property of 1-[(2-Chlorophenyl)(phenyl)methyl]piperazine

Chemical Property:

• Boiling Point: 154 °C(Press: 0.01 Torr)
• PKA: 8.98±0.10(Predicted)
• Density: 1.158±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 286.1236763
• Heavy Atom Count: 20
• Complexity: 285

Purity/Quality:

98% ^*data from raw suppliers

1-[(2-Chlorophenyl)phenylmethyl]piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CCN1)C(C2=CC=CC=C2)C3=CC=CC=C3Cl
• Uses: 1-[(2-Chlorophenyl)phenylmethyl]piperazine is a novel compound derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one).

Technology Process of 1-[(2-Chlorophenyl)(phenyl)methyl]piperazine

There total 3 articles about 1-[(2-Chlorophenyl)(phenyl)methyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 2-chloro-benzhydryl chloride (56961-47-8,33169-83-4) → 1-((2-chlorophenyl)(phenyl)methyl)piperazine (109036-15-9)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2010.01.008

Reference yield:

piperazine (110-85-0) → 1-((2-chlorophenyl)(phenyl)methyl)piperazine (109036-15-9)

Guidance literature:

Reference yield:

→ 1-((2-chlorophenyl)(phenyl)methyl)piperazine (109036-15-9)

Guidance literature:

2-Chlor-benzhydrol, 1) HCl, 2) Piperazin;

upstream raw materials:

piperazine

2-chloro-benzhydryl chloride

Downstream raw materials:

C₃₂H₃₁ClN₂O

2-{4-[(2-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-N,N-diphenyl-acetamide

4-[(2-chloro-phenyl)-phenyl-methyl]-piperazine-1-carboxylic acid benzhydryl-amide

1-{4-[(2-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-2-diphenylamino-ethanone

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