p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

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Chemical Name:p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate
CAS No.:300767-72-0
Molecular Formula:C₅₉H₄₇Cl₂N₅O₆S₂
Molecular Weight:1057.09
Hs Code.:

Synonyms:p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

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Chemical Property of p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

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Technology Process of p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

There total 3 articles about p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride

: 253160-40-6
(Z)-2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetic acid

: 300767-72-0
p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

Guidance literature:: With pyridine; trichlorophosphate; In dichloromethane; at -40 ℃; for 1h;
DOI:10.1016/S0040-4020(00)00415-4

Reference yield:

: 76-83-5
trityl chloride

: 300767-72-0
p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N

2: 75 percent / POCl₃; pyridine / CH₂Cl₂ / 1 h / -40 °C

With pyridine; triethylamine; trichlorophosphate; In dichloromethane; 1: Substitution / 2: Substitution;
DOI:10.1016/S0040-4020(00)00415-4

Reference yield:

: 189449-52-3
(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(triphenylmethoxyimino)acetic acid

: 300767-72-0
p-methoxybenzyl (6R,7R)-7(Z)-[2-(5-chloro-2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-chloromethyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N

2: 75 percent / POCl₃; pyridine / CH₂Cl₂ / 1 h / -40 °C

With pyridine; triethylamine; trichlorophosphate; In dichloromethane; 1: Substitution / 2: Substitution;
DOI:10.1016/S0040-4020(00)00415-4