1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Chemical Name:1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
CAS No.:1310458-60-6
Molecular Formula:C₂₃H₂₂F₃N₅O₄
Molecular Weight:489.454
Hs Code.:

Synonyms:1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Chemical Property of 1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

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Technology Process of 1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

There total 10 articles about 1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1310521-60-8
C₈H₁₇N₃O

: 1310458-60-6
1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.026

Reference yield:

: C₁₄H₂₄N₂O₅

: 1310458-60-6
1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 2 h / -15 °C

2: ammonia / dichloromethane / 2 h / 0 °C

3: sodium hypobromide / acetonitrile / 10 h / 5 °C

4: hydrogenchloride / dichloromethane / 1 h / 20 °C

5: triethylamine / acetonitrile / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hypobromide; ammonia; triethylamine; In dichloromethane; acetonitrile; 3: Hofmann degradation;
DOI:10.1016/j.ejmech.2011.03.026

Reference yield:

: C₁₉H₃₂N₂O₇

: 1310458-60-6
1-(2,4-difluorophenyl)-6-fluoro-7-(4-amino-3-ethoxyimino-4-methylpiperidin-1-yl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / dichloromethane / 2 h / 0 °C

2: sodium hypobromide / acetonitrile / 10 h / 5 °C

3: hydrogenchloride / dichloromethane / 1 h / 20 °C

4: triethylamine / acetonitrile / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hypobromide; ammonia; triethylamine; In dichloromethane; acetonitrile; 2: Hofmann degradation;
DOI:10.1016/j.ejmech.2011.03.026