(S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Base Information

Chemical Name:(S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:1466565-11-6
Molecular Formula:C₂₅H₂₁N₇O₃
Molecular Weight:467.487
Hs Code.:

Synonyms:(S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Property of (S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Technology Process of (S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

There total 11 articles about (S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1466564-97-5
(S)-2-amino-N-(1-(8-formyl-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide hydrochloride

: 1466565-11-6
(S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In methanol; dichloromethane; at 23 ℃; for 3h;
DOI:10.1021/acsmedchemlett.6b00238

Reference yield:

: 1466566-07-3
C₃₂H₂₈N₆O₄

: 1466565-11-6
(S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate / tetrahydrofuran; water / 24 h / 20 °C

2: triethylamine; hydroxylamine hydrochloride / dichloromethane; methanol / 3 h / 25 °C

With sodium periodate; hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1466563-96-1
C₂₉H₂₇ClN₆O₄

: 1466565-11-6
(S)-2-amino-N-(1-(8-((hydroxyimino)methyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: sodium carbonate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

3: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; water; tert-butyl alcohol / 20 °C

4: sodium periodate / tetrahydrofuran; water / 24 h / 20 °C

5: triethylamine; hydroxylamine hydrochloride / dichloromethane; methanol / 3 h / 25 °C

With sodium periodate; osmium(VIII) oxide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydroxylamine hydrochloride; sodium carbonate; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; tert-butyl alcohol;