Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI)

Base Information

Chemical Name:Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI)
CAS No.:439090-12-7
Molecular Formula:C₆H₁₀FNO₂
Molecular Weight:147.149
Hs Code.:
Mol file:439090-12-7.mol

Synonyms:Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI)

Suppliers and Price of Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI)

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI)

There total 18 articles about Cyclobutanecarboxylic acid, 1-amino-3-(fluoromethyl)-, trans- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 439090-09-2
syn-1-[N-(tert-butoxycarbonyl)amino]-3-fluoromethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

: 439090-12-7
cis-1-amino-3-fluoromethylcyclobutane-1-carboxylic acid

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 0.5h;
DOI:10.1021/jm010242p

Reference yield: 73.0%

: 439090-10-5
anti-1-[N-(tert-butoxycarbonyl)amino]-3-fluoromethyl-1-cyclobutane-1-carboxylic acid t-butyl ester

: 439090-12-7
trans-1-amino-3-fluoromethylcyclobutane-1-carboxylic acid

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 0.5h;
DOI:10.1021/jm010242p

Reference yield:

: 172324-67-3
3-benzyloxymethyl-cyclobutanone

: 439090-12-7
cis-1-amino-3-fluoromethylcyclobutane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 50 percent / aq. (NH₄)2CO₃; aq. NH₄Cl / ethanol / 72 h / 60 °C

2: aq. NaOH / 12 h / 120 °C

3: Et₃N / methanol / 12 h / 20 °C

4: 89 percent / CH₂Cl₂ / 15 h / 20 °C

5: 100 percent / H₂ / Pd/C / methanol / 3 h

6: 79 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 20 °C

7: 50 percent / tetrabutylammonium fluoride / tetrahydrofuran / 96 h / 20 °C

8: 87 percent / aq. HCl / methanol / 0.5 h / 60 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydroxide; tetrabutyl ammonium fluoride; hydrogen; ammonium carbonate; ammonium chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm010242p