1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane

Base Information

• Chemical Name: 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane
• CAS No.: 799557-61-2
• Molecular Formula: C₂₃H₃₂N₄O₃
• Molecular Weight: 412.532
• Mol file: 799557-61-2.mol

Synonyms:1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane

Chemical Property of 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane

There total 1 articles about 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-cyanophenyl)piperidine-4-carboxylic acid (162997-21-9) + tert-butyl 1,4-diazepine-1-carboxylate (112275-50-0) → 1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane (799557-61-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield:

1-tert-butoxycarbonyl-4-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane (799557-61-2) → 1-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane (807319-90-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

1-(4-cyanophenyl)piperidine-4-carboxylic acid

tert-butyl 1,4-diazepine-1-carboxylate

Downstream raw materials:

1-[1-(4-cyanophenyl)-piperidine-4-carbonyl]-[1,4]diazepane

Refernces