methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

Base Information

Chemical Name:methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate
CAS No.:114968-40-0
Molecular Formula:C₂₆H₂₁Cl₂N₃O₆
Molecular Weight:542.375
Hs Code.:

Synonyms:methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

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Chemical Property of methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

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Technology Process of methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

There total 3 articles about methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.3%

: 64027-19-6
2-(2,2-dichloroacetoxyimino)phenylacetyl chloride

: 63854-87-5,114968-39-7
(R)-((S)-3-Amino-2-oxo-azetidin-1-yl)-naphthalen-1-yl-acetic acid methyl ester

: 114968-40-0
methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

Guidance literature:: DOI:10.1248/cpb.35.3985

Reference yield:

: 63856-38-2,64232-16-2,64232-17-3,115016-09-6,115016-10-9
methyl 2-(1-naphthyl)-2-(2-oxo-3-phthalimido-1-azetidinyl)acetate

: 114968-40-0
methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-1,3-propanediamine / methanol; CHCl₃ / Ambient temperature

2: 74.3 percent

With 1-amino-3-(dimethylamino)propane; In methanol; chloroform;
DOI:10.1248/cpb.35.3985

Reference yield:

: 63856-08-6,115016-06-3
trimethyl α,α',α''-tri(1-naphthyl)hexahydro-1,3,5-triazine-1,3,5-triacetate

: 114968-40-0
methyl (3RS,αSR)-2-<3-(2,2-dichloroacetoxyimino-2-phenylacetamido)-2-oxo-1-azetidinyl>-2-(1-naphthyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 43.3 percent / BF₃*OEt₂ / 1.) pyridine, CH₂Cl₂, -78 deg C, 2 h; 2.) 1 h, 0 deg C

2: N,N-dimethyl-1,3-propanediamine / methanol; CHCl₃ / Ambient temperature

3: 74.3 percent

With boron trifluoride diethyl etherate; 1-amino-3-(dimethylamino)propane; In methanol; chloroform;
DOI:10.1248/cpb.35.3985