5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

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Chemical Name:5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS No.:1333167-73-9
Molecular Formula:C₂₅H₂₂N₄O₅S
Molecular Weight:490.539
Hs Code.:

Synonyms:5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

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Chemical Property of 5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

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Technology Process of 5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

There total 6 articles about 5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 467468-18-4
5-(4-phenoxyphenyl)-5-(piperazin-1-yl)pyrimidine-2,4,6 (1H,3H,5H)-trione

: 1333167-73-9
5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: With triethylamine; In tetrahydrofuran; at -70 ℃;
DOI:10.1016/j.bmc.2011.06.055

Reference yield:

: 5-bromo-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

: 1333167-73-9
5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: triethylamine / tetrahydrofuran / -70 °C

With triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2011.06.055

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1333167-73-9
5-(4-(thiophene-2-carbonyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine; copper diacetate / dichloromethane / 20 h / 20 °C / Molecular sieve

2: sodium hydride / tetrahydrofuran / 6 h / 100 - 105 °C

3: ethanol; sodium / 7 h / 100 °C

4: hydrogen bromide; bromine / water / 0 - 10 °C

5: methanol / 24 h / 20 °C

6: triethylamine / tetrahydrofuran / -70 °C

With pyridine; ethanol; hydrogen bromide; bromine; copper diacetate; sodium; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2011.06.055