2,5-dichloro-1H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 2,5-dichloro-1H-imidazo[4,5-b]pyridine
• CAS No.: 438190-90-0
• Molecular Formula: C₆H₃Cl₂N₃
• Molecular Weight: 188.016
• Hs Code.: 2933990090
• Mol file: 438190-90-0.mol

Synonyms:1H-Imidazo[4,5-b]pyridine,2,5-dichloro- (9CI);

Chemical Property of 2,5-dichloro-1H-imidazo[4,5-b]pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.724
• Boiling Point: 379.408 °C at 760 mmHg
• PKA: 6.52±0.40(Predicted)
• Flash Point: 215.167 °C
• PSA: 41.57000
• Density: 1.675g/cm³
• LogP: 2.26470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Dichloro-1H-imidazo[4,5-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dichloro-1H-imidazo[4,5-b]pyridine

There total 1 articles about 2,5-dichloro-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,5-dichloro-3H-imidazo[4,5-b]pyridine (438190-90-0)

Guidance literature:

Reference yield:

2,5-dichloro-3H-imidazo[4,5-b]pyridine (438190-90-0) → tert-butyl (1-(5-((3-aminophenyl)thio)-3H-imidazo[4,5-b]pyridin-2-yl)-4-methylpiperidin-4-yl)carbamate

Guidance literature:

Multi-step reaction with 2 steps

1: 4-methyl-morpholine / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C / Microwave irradiation

2: 4-methyl-morpholine / 1-methyl-pyrrolidin-2-one / 0.75 h / 230 °C / Microwave irradiation

With 4-methyl-morpholine; In 1-methyl-pyrrolidin-2-one;

Reference yield:

2,5-dichloro-3H-imidazo[4,5-b]pyridine (438190-90-0) → tert-butyl 5-((3-aminophenyl)thio)-2-(4-((tert-butoxycarbonyl)amino)-4-methylpiperidin-1-yl)-3H-imidazo[4,5-b]pyridine-3-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine / 1-methyl-pyrrolidin-2-one / 1 h / 110 °C / Microwave irradiation

2: 4-methyl-morpholine / 1-methyl-pyrrolidin-2-one / 0.75 h / 230 °C / Microwave irradiation

3: triethylamine / tetrahydrofuran / 4 h / 70 °C

With 4-methyl-morpholine; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Refernces