N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

Base Information

Chemical Name:N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid
CAS No.:1000183-40-3
Molecular Formula:C₂HF₃O₂*C₂₇H₃₁FN₈O
Molecular Weight:616.618
Hs Code.:

Synonyms:N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

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Chemical Property of N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

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Technology Process of N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

There total 11 articles about N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000183-39-0
N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide

: 76-05-1
trifluoroacetic acid

: 1000183-40-3
N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

Guidance literature:: In water; acetonitrile;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1000183-40-3
N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: N-Bromosuccinimide / dichloromethane / 12 h

3.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

3.2: 2.5 h / 20 °C

3.3: 0.5 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

5.1: 1,4-dioxane / 12 h / 150 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: water; acetonitrile

With dmap; N-Bromosuccinimide; Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetonitrile;

Reference yield:

: 1000183-46-9
3-bromo-5-fluoro-1-Boc-1H-indole

: 1000183-40-3
N-[2-(dimethylamino)ethyl]-4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

1.2: 2.5 h / 20 °C

1.3: 0.5 h

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

3.1: 1,4-dioxane / 12 h / 150 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: water; acetonitrile

With Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetonitrile;