(2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid
CAS No.:1194056-65-9
Molecular Formula:C₂₁H₂₃NO₆
Molecular Weight:385.417
Hs Code.:

Synonyms:(2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

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Chemical Property of (2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

Chemical Property:

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Technology Process of (2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

There total 1 articles about (2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1194056-65-9
(2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

Guidance literature:: (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

p-methoxybenzyl chloride; In tetrahydrofuran; mineral oil; at 20 - 65 ℃;

Reference yield:

: 1194056-65-9
(2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

: 1194056-66-0
(2S,4R)-benzyl-2-(hydroxymethyl)-4-(4-methoxybenzyloxy)pyrrolidine-1-carboxylate

Guidance literature:: (2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With methanol; water; In tetrahydrofuran;

Reference yield:

: 1194056-65-9
(2S,4R)-1-(benzyloxycarbonyl)-4-(4-methoxybenzyloxy)pyrrolidine-2-carboxylic acid

: 1194056-67-1
(2S,4R)-benzyl-2-formyl-4-(4-methoxybenzyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With borane-THF; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;