[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

Base Information

Chemical Name:[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester
CAS No.:179815-56-6
Molecular Formula:C₂₉H₄₆O₅SSi₂
Molecular Weight:562.918
Hs Code.:

[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

Synonyms:[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

Suppliers and Price of [(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

There total 1 articles about [(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 114066-25-0
(3aR,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-3-one

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 179815-56-6
[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

Guidance literature:: In toluene; at 110 ℃;
DOI:10.1021/ja961071u

Reference yield: 74.0%

: 179815-56-6
[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

: 179815-57-7
2-[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at -78 ℃;
DOI:10.1021/ja961071u

Reference yield:

: 179815-56-6
[(3aS,4S,5S,7aR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methyl-5-phenylsulfanyl-3a-trimethylsilanyloxy-3a,4,5,7a-tetrahydro-benzofuran-(3E)-ylidene]-acetic acid ethyl ester

: 179815-64-6
C₃₉H₅₂O₇S

Guidance literature:: Multi-step reaction with 11 steps

1: 74 percent / LiAlH₄ / diethyl ether / -78 °C

2: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 35 min, 2.) CH₂Cl₂, -78 deg C, 15 min

3: 1.) MeLi-LiBr / 1.) THF, -78 deg C, 2.) THF, -78 deg C, 3.5 h

4: I₂ / benzene / 2 h / 25 °C

5: 72 percent / K₂CO₃ / methanol

6: 87 percent / 2,6-lutidine / CH₂Cl₂

7: 62 percent / Pr₄NRuO₄, NMO / CH₂Cl₂ / 25 °C

8: 74 percent / NaClO₂, Na₂HPO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 25 °C

9: 83 percent / n-Bu₄NF / tetrahydrofuran

10: 57 percent / DCC, DMAP, HCl / CHCl₃ / 70 °C

11: 90 percent / m-CPBA / CH₂Cl₂ / -78 °C

With 2,6-dimethylpyridine; hydrogenchloride; dmap; sodium chlorite; disodium hydrogenphosphate; lithium aluminium tetrahydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; methyllithium; iodine; potassium carbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; lithium bromide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; tert-butyl alcohol; benzene;
DOI:10.1021/ja961071u