(11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one

Base Information

• Chemical Name: (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one
• CAS No.: 1026668-55-2
• Molecular Formula: C₂₈H₂₉F₅O₄
• Molecular Weight: 524.528

Synonyms:(11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one

Chemical Property of (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one

There total 5 articles about (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

20,20,21,21,21-pentafluoro-5,17-dihydroxy-11β-[4-[2-(hydroxymethyl)-1,3-dioxolan-2-yl]phenyl]-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal → (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one (1026668-55-2)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water; at 23 ℃; for 2.5h; Product distribution / selectivity;

Reference yield: 80.0%

(5R,8S,11R,13S,14S,17S)-11-{4-[2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1,3-dioxolan-2-yl]phenyl}-5',5',13-trimethyl-17-(pentafluoroethyl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17(4H)-diol → (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one (1026668-55-2)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water; at 23 ℃; for 2.5h; Product distribution / selectivity;

Reference yield:

20,20,21,21,21-pentafluoro-11β-[4-(hydroxyacetyl)phenyl]-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal (1026668-63-2) → (11β,17β)-20,20,21,21,21-pentafluoro-11-(4-glycoloylphenyl)-17-hydroxy-19-norpregna-4,9-dien-3-one (1026668-55-2)

Guidance literature:

With sulfuric acid; In methanol; water; at 20 ℃; for 1h; Product distribution / selectivity;

upstream raw materials:

20,20,21,21,21-pentafluoro-11β-[4-(hydroxyacetyl)phenyl]-5,17-dihydroxy-19-nor-5α,17α-pregn-9-en-3-one 2,2-dimethylpropane-1,3-diyl ketal

(5′R,8′S,10′R,13′S,14′S)-5,5,13′-trimethyl-1′,2′,6′,7′,8′,12′,13′,14′,15′,16′-decahydro-17′H-spiro[1,3-dioxane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-one

(5′R,8′S,10′R,13′S,14′S,17′S)-5,5,13′-trimethyl-17′-(pentafluoroethyl)-1′,2′,7′,8′,12′,13′,14′,15′,16′,17′-decahydro-6′H-spiro[1,3-dioxane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-ol

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