4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

Base Information

Chemical Name:4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate
CAS No.:1572039-78-1
Molecular Formula:C₁₉H₂₂N₂O₇S
Molecular Weight:422.459
Hs Code.:

Synonyms:4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

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Chemical Property of 4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

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Technology Process of 4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

There total 5 articles about 4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 18997-12-1
4-nitrophenyl sulfurochloridate

: 1572039-77-0
(4R)-4-aminomethyl-5,5-dimethyl-2-phenyl-1,3-dioxane

: 1572039-78-1
4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

Guidance literature:: With 4-nitro-phenol; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1016/j.bmc.2014.01.017

Reference yield:

: 774-48-1
(diethoxymethyl)benzene

: 1572039-78-1
4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1: camphor-10-sulfonic acid / dichloromethane / 24 h / 23 °C / Reflux

2: triethylamine / dichloromethane / 16 h / 0 - 23 °C

3: sodium azide / N,N-dimethyl-formamide / 16 h / 100 °C

4: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 23 °C

5: 4-nitro-phenol / dichloromethane / 2 h / -78 °C

With sodium azide; 4-nitro-phenol; palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.01.017

Reference yield:

: 1572039-76-9
(4R)-4-azidomethyl-5,5-dimethyl-2-phenyl-1,3-dioxane

: 1572039-78-1
4-nitrophenyl-[((4R)-5,5-dimethyl-2-phenyl-1,3-dioxan-4-yl)methyl]sulfamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 23 °C

2: 4-nitro-phenol / dichloromethane / 2 h / -78 °C

With 4-nitro-phenol; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2014.01.017