7-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine

Base Information

• Chemical Name: 7-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine
• CAS No.: 437384-07-1
• Molecular Formula: C13H8 Cl F N2
• Molecular Weight: 246.671
• DSSTox Substance ID: DTXSID90458036
• Nikkaji Number: J1.967.591B
• Wikidata: Q82281159
• Mol file: 437384-07-1.mol

Synonyms:7-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine;437384-07-1;SCHEMBL5452887;DTXSID90458036;ATENWFZPEVYXTK-UHFFFAOYSA-N;2-(4-Fluorophenyl)-7-chloropyrazolo[1,5-a]pyridine;7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-alpha]pyridine;7-chloro-2-(4-fluorophenyl)pyrazolo[1.5-alpha]pyridine

Chemical Property of 7-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine

Chemical Property:

• PSA: 17.30000
• LogP: 3.79380
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 246.0360041
• Heavy Atom Count: 17
• Complexity: 268

Purity/Quality:

95% ^*data from raw suppliers

7-CHLORO-2-(4-FLUOROPHENYL)PYRAZOLO[1,5-A]PYRIDINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC2=CC(=NN2C(=C1)Cl)C3=CC=C(C=C3)F

Technology Process of 7-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine

There total 4 articles about 7-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(6-Chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone oxime + iron(II) chloride → 7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine (437384-07-1)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In 1,2-dimethoxyethane;

Reference yield:

2-chloro-6-[3-(4-fluoro-phenyl)-2H-azirin-2-yl]-pyridine (637775-51-0) → 7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine (437384-07-1)

Guidance literature:

With iron(II) chloride; In 1,2-dimethoxyethane; for 3h; Heating;

DOI:10.1016/j.tet.2003.02.003

Reference yield:

2-(6-chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone (437384-05-9) → 7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine (437384-07-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / hydroxylamine hydrochloride; aq. NaOH / methanol / 2 h / Heating

2: 1,2-dimethoxy-ethane / 0 - 15 °C

3: Et₃N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C

4: 69.7 g / FeCl₂ / 1,2-dimethoxy-ethane / 3 h / Heating

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; iron(II) chloride; In methanol; 1,2-dimethoxyethane;

DOI:10.1016/j.tet.2003.02.003

upstream raw materials:

2-chloro-6-[3-(4-fluoro-phenyl)-2H-azirin-2-yl]-pyridine

2-(6-chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone

2-(6-chloro-2-pyridinyl)-1-(4-fluorophenyl)ethanone oxime

Downstream raw materials:

1-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]ethanone

7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

(2E)-1-[7-(cyclopentylamino)-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-3-(dimethylamino)-2-propen-1-one

4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine