2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide

Base Information

• Chemical Name: 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide
• CAS No.: 220493-40-3
• Molecular Formula: C₃₉H₃₃N₅O₆
• Molecular Weight: 667.721
• Mol file: 220493-40-3.mol

Synonyms:2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide

Chemical Property of 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide

There total 5 articles about 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 3-amino benzophenone (2835-78-1) + 2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-(4-methoxyphenyl)-N-methylacetamide (220493-50-5) → 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide (220493-40-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; Multistep reaction; 1.) CH₃CN, 4 deg C, 2.) CH₃CN, 4 deg C;

DOI:10.1016/S0960-894X(98)00548-4

Reference yield:

2-bromo-N-(4-methoxyphenyl)-N-methylacetamide (948551-23-3) → 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide (220493-40-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 20 °C

2.1: 8.0 g / tetrahydrofuran / 16 h / 20 °C

3.1: 95.3 percent / zinc; acetic acid / 20 °C

4.1: diisopropylethylamine / acetonitrile / 0.5 h / 4 °C

4.2: 300 mg / diisopropylethylamine / acetonitrile / 4 °C

With potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm049072h

Reference yield:

N-(4-methoxy-phenyl)-N-methyl-2-(2-phenylamino-phenylamino)-acetamide (875552-56-0) → 2-{3-[3-(4-benzoylphenyl)ureido]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl}-N-(4-methoxyphenyl)-N-methylacetamide (220493-40-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 8.0 g / tetrahydrofuran / 16 h / 20 °C

2.1: 95.3 percent / zinc; acetic acid / 20 °C

3.1: diisopropylethylamine / acetonitrile / 0.5 h / 4 °C

3.2: 300 mg / diisopropylethylamine / acetonitrile / 4 °C

With acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm049072h

upstream raw materials:

bis(trichloromethyl) carbonate

3-amino benzophenone

2-[3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl]-N-(4-methoxyphenyl)-N-methylacetamide

2-bromo-N-(4-methoxyphenyl)-N-methylacetamide