1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

Base Information

Chemical Name:1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione
CAS No.:348620-47-3
Molecular Formula:C₂₄H₂₄N₂O₆S
Molecular Weight:468.53
Hs Code.:

Synonyms:1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

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Chemical Property of 1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

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Technology Process of 1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

There total 9 articles about 1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 348620-36-0
1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

: 348620-47-3
1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

Guidance literature:: With tetraphosphorus decasulfide; In tetrahydrofuran; at 70 ℃; for 7h;
DOI:10.1021/jo001580l

Reference yield:

: 26011-68-7
methyl N-(2-phenylethyl)carbamate

: 348620-47-3
1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

2: 76 percent / KOH; N₂H₄*H₂O / ethane-1,2-diol / 110 °C

3: 83 percent / Et₃N; DMAP / ethyl acetate / 0 - 20 °C

4: 87 percent / Mn(OAc)3*2H₂O; Cu(OAc)2*H₂O / acetic acid / 20 °C

5: 69 percent / CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide / 18 h / 70 °C

6: 55 percent / NH₄NO₃; (CF₃CO)2O / CH₂Cl₂ / 7 h / 20 °C

7: 76 percent / P₄S₁₀ / tetrahydrofuran / 7 h / 70 °C

With ammonium nitrate; dmap; potassium hydroxide; copper(l) iodide; tetraphosphorus decasulfide; copper diacetate; manganese triacetate; tetra-(n-butyl)ammonium iodide; sodium hydride; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic anhydride; palladium diacetate; In tetrahydrofuran; dichloromethane; ethylene glycol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 5: Heck reaction;
DOI:10.1021/jo001580l

Reference yield:

: 64-04-0
phenethylamine

: 348620-47-3
1-(4'-nitrophenethyl)-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinethione

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / K₂CO₃ / acetone / Heating

2: 88 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

3: 76 percent / KOH; N₂H₄*H₂O / ethane-1,2-diol / 110 °C

4: 83 percent / Et₃N; DMAP / ethyl acetate / 0 - 20 °C

5: 87 percent / Mn(OAc)3*2H₂O; Cu(OAc)2*H₂O / acetic acid / 20 °C

6: 69 percent / CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide / 18 h / 70 °C

7: 55 percent / NH₄NO₃; (CF₃CO)2O / CH₂Cl₂ / 7 h / 20 °C

8: 76 percent / P₄S₁₀ / tetrahydrofuran / 7 h / 70 °C

With ammonium nitrate; dmap; potassium hydroxide; copper(l) iodide; tetraphosphorus decasulfide; copper diacetate; manganese triacetate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic anhydride; palladium diacetate; In tetrahydrofuran; dichloromethane; ethylene glycol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone; 6: Heck reaction;
DOI:10.1021/jo001580l