1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

Base Information

Chemical Name:1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine
CAS No.:79106-50-6
Molecular Formula:C₂₃H₂₈N₂O₅
Molecular Weight:412.486
Hs Code.:

Synonyms:1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

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Chemical Property of 1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

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Technology Process of 1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

There total 7 articles about 1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

: 79106-48-2
1-(3,4-dimethoxybenzoylmethyl)-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

: 79106-50-6
1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1248/cpb.33.1104

Reference yield:

: 1205-72-7
1-benzyl-4-amino-piperidine dihydrochloride

: 79106-50-6
1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 2) NaBH₄ / 1) methanol, room temp, 1 h; 2) room temp. 2 h

2: 77.3 percent / tetrahydrofuran / 0.5 h / Heating

3: 84.9 percent / hydrogen, 1N HCl / 10percent Pd-C / H₂O; methanol / 40 °C

4: 80.3 percent / TEA / methanol / 48 h / Ambient temperature

5: 83.4 percent / NaBH₄ / methanol

With hydrogenchloride; sodium tetrahydroborate; TEA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1248/cpb.33.1104

Reference yield:

: 90-02-8
salicylaldehyde

: 79106-50-6
1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 2) NaBH₄ / 1) methanol, room temp, 1 h; 2) room temp. 2 h

2: 77.3 percent / tetrahydrofuran / 0.5 h / Heating

3: 84.9 percent / hydrogen, 1N HCl / 10percent Pd-C / H₂O; methanol / 40 °C

4: 80.3 percent / TEA / methanol / 48 h / Ambient temperature

5: 83.4 percent / NaBH₄ / methanol

With hydrogenchloride; sodium tetrahydroborate; TEA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1248/cpb.33.1104