tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

Base Information

Chemical Name:tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate
CAS No.:1620294-58-7
Molecular Formula:C₂₁H₂₄FN₃O₄
Molecular Weight:401.438
Hs Code.:

Synonyms:tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

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Chemical Property of tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

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Technology Process of tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

There total 2 articles about tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 41404-58-4
2-bromo-5-fluoropyridine

: 1620294-56-5
tert-butyl ((5-((2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

: 1620294-58-7
tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1620294-98-5
tert-butyl ((5-((2-bromophenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

: 1620294-58-7
tert-butyl ((5-((2-(5-fluoropyridin-2-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In 1,4-dioxane; water; 2: |Suzuki Coupling;