4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone

Base Information

• Chemical Name: 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone
• CAS No.: 1354791-03-9
• Molecular Formula: C₂₃H₃₂N₄O₇
• Molecular Weight: 476.53
• Mol file: 1354791-03-9.mol

Synonyms:4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone

Chemical Property of 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone

There total 5 articles about 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-di(tert-butoxycarbonyl)hydroxylamine (85006-25-3) + 4-(acetyl-O-methoxyoxime)-4-bromo-3-methy-1-phenyl-1H-pyrazol-5(4H)-one (1354791-02-8) → 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone (1354791-03-9)

Guidance literature:

N,N-di(tert-butoxycarbonyl)hydroxylamine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

4-(acetyl-O-methoxyoxime)-4-bromo-3-methy-1-phenyl-1H-pyrazol-5(4H)-one; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone (1354791-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / water; Petroleum ether; tert-butyl methyl ether

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 0.5 h / 20 °C

With sodium hydride; triethylamine; In tert-butyl methyl ether; water; N,N-dimethyl-formamide; mineral oil; Petroleum ether;

Reference yield:

4-(acetyl-O-methoxyoxime)-N-phenyl-5-methylpyrazolone → 4-(acetyl-O-methoxyoxime)-4-(N-(N,O-bis(t-butoxycarbonyl))hydroxylamine)-N-phenyl-5-methylpyrazolone (1354791-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromine; sodium hydrogencarbonate / water; dichloromethane / 0.08 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 0.5 h / 20 °C

With bromine; sodium hydride; sodium hydrogencarbonate; In dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

edaravone

1-Phenyl-3-methyl-4-acetyl-5-pyrazolon

N,N-di(tert-butoxycarbonyl)hydroxylamine

4-(acetyl-O-methoxyoxime)-4-bromo-3-methy-1-phenyl-1H-pyrazol-5(4H)-one

Downstream raw materials:

4-(N-hydroxylamine)-4-(acetyl-O-methoxyoxime)-N-phenyl-5-methyl-pyrazolone

Refernces