(17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

Base Information

Chemical Name:(17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester
CAS No.:95689-19-3
Molecular Formula:C₂₉H₃₀N₂O₅
Molecular Weight:486.568
Hs Code.:

Synonyms:(17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

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Chemical Property of (17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

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Technology Process of (17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

There total 3 articles about (17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 95689-16-0
(1R,3S)-2-Benzyl-1-((1R,3R,4S,8S)-3-methoxy-5,7-dimethylene-2,6-dioxa-bicyclo[2.2.2]oct-8-ylmethyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

: 95689-21-7
C₂₉H₂₈N₂O₄

: 95689-19-3
(17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

Guidance literature:: With water; hydrogenchloride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)91319-5

Reference yield:

: 63229-68-5
methyl N-benzyl-L-tryptophanate

: 95689-19-3
(17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / toluene / 60 deg C, 12 h, then 70-75 deg C, 48 h

2: 72 percent / H₂O / conc.HCl / tetrahydrofuran / 1 h / Ambient temperature

With water; magnesium sulfate; hydrogenchloride; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)91319-5

Reference yield:

: 95689-14-8
((1R,3R,4S,8S)-3-Methoxy-5,7-dimethylene-2,6-dioxa-bicyclo[2.2.2]oct-8-yl)-acetaldehyde

: 95689-19-3
(17R,20E)-4-benzyl-17,21-epoxy-17-hydroxy-16-methylen-19-oxo-3β-4,21-secocoryn-20-en-5β-carbonsaeure-methylester

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / toluene / 60 deg C, 12 h, then 70-75 deg C, 48 h

2: 72 percent / H₂O / conc.HCl / tetrahydrofuran / 1 h / Ambient temperature

With water; magnesium sulfate; hydrogenchloride; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)91319-5