2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one
CAS No.:1169549-67-0
Molecular Formula:C₁₇H₁₁ClN₂O₃
Molecular Weight:326.739
Hs Code.:

Synonyms:2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

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Chemical Property of 2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

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Technology Process of 2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

There total 2 articles about 2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-amino-5-methoxybenzofuran-2-carboxamide

: 89-98-5
2-chloro-benzaldehyde

: 1169549-67-0
2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: 3-amino-5-methoxybenzofuran-2-carboxamide; 2-chloro-benzaldehyde; With hydrogenchloride; In ethanol; at 20 ℃;

With oxygen; sodium hydrogensulfite; In ethanol; dimethyl sulfoxide; at 150 ℃; for 5h;

Reference yield:

: 1380495-85-1
C₁₀H₁₀N₂O₃

: 1169549-67-0
2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 75 °C

2: Acidic conditions; Heating

With potassium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2012.04.025

Reference yield: 90.0%

: 1169549-67-0
2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

: 1169550-49-5
2-(2-chlorophenyl)-8-hydroxy[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: 2-(2-chlorophenyl)-8-(methyloxy)[1]benzofuro[3,2-d]pyrimidin-4(3H)-one; With boron tribromide-dimethyl sulfide complex; In 1,2-dichloro-ethane; for 8h; Heating / reflux;

With water; In 1,2-dichloro-ethane; at 20 ℃;