(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole
CAS No.:227089-87-4
Molecular Formula:C₁₅H₂₁NO₃
Molecular Weight:263.337
Hs Code.:

Synonyms:(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

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Chemical Property of (-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

Chemical Property:

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Technology Process of (-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

There total 4 articles about (-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(1-hydroxymethyl-2-methyl-propyl)-2,3-dimethoxy-5-methyl-benzamide

: 227089-87-4
(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

Guidance literature:: N-(1-hydroxymethyl-2-methyl-propyl)-2,3-dimethoxy-5-methyl-benzamide; With thionyl chloride; In dichloromethane; at 20 ℃; for 15h;

With potassium carbonate; In water; acetonitrile; for 15h; Heating;
DOI:10.1071/CH99134

Reference yield:

: 90919-49-6
2,3-Dimethoxy-5-methylbenzoyl chloride

: 227089-87-4
(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 15 h / 20 °C

2.1: SOCl₂ / CH₂Cl₂ / 15 h / 20 °C

2.2: 3.6 g / K₂CO₃ / H₂O; acetonitrile / 15 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1071/CH99134

Reference yield:

: 5653-56-5
2,3-dimethoxy-5-methylbenzoic acid

: 227089-87-4
(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl chloride; N,N-dimethylformamide / CH₂Cl₂ / 15 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 15 h / 20 °C

3.1: SOCl₂ / CH₂Cl₂ / 15 h / 20 °C

3.2: 3.6 g / K₂CO₃ / H₂O; acetonitrile / 15 h / Heating

With thionyl chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1071/CH99134