N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

Base Information

Chemical Name:N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine
CAS No.:858103-14-7
Molecular Formula:C₃₂H₃₃F₂N₃O₇S
Molecular Weight:641.693
Hs Code.:

Synonyms:N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

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Chemical Property of N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

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Technology Process of N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

There total 8 articles about N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 858104-44-6
tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate

: 858103-14-7
N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

Guidance literature:: Multi-step reaction with 9 steps

1.1: titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 0.08 h / 0 °C

1.2: 0.33 h / -40 - 0 °C

2.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 1 h / 90 °C

2.2: 18 h / 45 °C

2.3: 6 h / 45 °C

3.1: dichloromethane / 2 h / 0 °C

4.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

4.2: 1.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

6.1: 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C

6.2: 25 h

7.1: trifluoroacetic acid / dichloromethane / 1 h

8.1: 4-methyl-morpholine / dichloromethane / 20 °C

8.3: 2 h

9.1: sodium tetrahydroborate / methanol

With 4-methyl-morpholine; titanium(IV) isopropylate; sodium tetrahydroborate; tributylphosphine; water; titanium tetrachloride; N,O-bis-(trimethylsilyl)-acetamide; trifluoroacetic acid; In methanol; dichloromethane; acetone; toluene;

Reference yield:

: 858104-50-4
(4-{(2R,3R)-1-(4-fluoro-phenyl)-3-[(RS)-2-(4-fluoro-phenyl)-2-oxoethylsulfanyl]-4-oxo-azetidin-2-yl}-phenoxy)-acetic acid

: 858103-14-7
N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C

1.2: 25 h

2.1: trifluoroacetic acid / dichloromethane / 1 h

3.1: 4-methyl-morpholine / dichloromethane / 20 °C

3.3: 2 h

4.1: sodium tetrahydroborate / methanol

With 4-methyl-morpholine; sodium tetrahydroborate; trifluoroacetic acid; In methanol; dichloromethane;

Reference yield:

: 858104-47-9
(3R,4R)-1-(4-fluorophenyl)-3-(4-methoxybenzylsulphanyl)-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one

: 858103-14-7
N-({4-[(2R,3R)-1-(4-fluorophenyl)-3-{[(2RS)-2-(4-fluorophenyl)-2-hydroxyethyl]thio}-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-D-valine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 2 h / 0 °C

2.1: tributylphosphine; water / acetone / 0.5 h / 20 °C

2.2: 1.5 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.1: 4-methyl-morpholine / dichloromethane / 0.17 h / 20 °C

4.2: 25 h

5.1: trifluoroacetic acid / dichloromethane / 1 h

6.1: 4-methyl-morpholine / dichloromethane / 20 °C

6.3: 2 h

7.1: sodium tetrahydroborate / methanol

With 4-methyl-morpholine; sodium tetrahydroborate; tributylphosphine; water; trifluoroacetic acid; In methanol; dichloromethane; acetone;