N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

Base Information

Chemical Name:N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide
CAS No.:1012054-99-7
Molecular Formula:C₃₁H₃₆N₄O₅
Molecular Weight:544.651
Hs Code.:

Synonyms:N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

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Chemical Property of N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

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Technology Process of N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

There total 15 articles about N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1012054-59-9
CUDC-101

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1012054-99-7
N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; acetone; at 0 - 20 ℃; for 1h;

Reference yield:

: 230955-75-6
6-acetoxy-4-chloro-7-methoxyquinazoline

: 1012054-99-7
N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 3 h / Heating / reflux

2: methanol; lithium hydroxide; water / 0.5 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

4: hydroxylamine / water / 24 h / 25 °C

5: triethylamine / N,N-dimethyl-formamide; acetone / 1 h / 0 - 20 °C

With methanol; lithium hydroxide; water; hydroxylamine; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;

Reference yield:

: 29823-18-5
ethyl 7-bromoheptanoate

: 1012054-99-7
N-(cyclohexanecarbonyloxy)-7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

2: hydroxylamine / water / 24 h / 25 °C

3: triethylamine / N,N-dimethyl-formamide; acetone / 1 h / 0 - 20 °C

With hydroxylamine; potassium carbonate; triethylamine; In water; N,N-dimethyl-formamide; acetone;