Technology Process of C17H19BrN2O2S*ClH
There total 9 articles about C17H19BrN2O2S*ClH which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 0 - 20 ℃;
for 14h;
- Guidance literature:
-
Multi-step reaction with 12 steps
1: sodium tetrahydroborate / methanol / 2 h / 0 °C
2: thionyl chloride / dichloromethane / 12 h / 0 - 20 °C
3: acetonitrile / 21 h / 20 °C / Reflux
4: potassium carbonate / methanol; water / 4 h / 20 °C
5: sulfuric acid / 2 h / Reflux
6: water / acetonitrile / 12 h / 40 °C
7: tetrahydrofuran / 1.5 h / 0 °C
8: acetic anhydride / 0.5 h / 20 - 90 °C
9: 0 °C
10: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / 0 - 20 °C
11: toluene / 1 h / Reflux
12: hydrogenchloride / 1,4-dioxane / 14 h / 0 - 20 °C
With
hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sulfuric acid; diphenyl phosphoryl azide; water; acetic anhydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; acetonitrile;
11: |Curtius Rearrangement;
DOI:10.1021/jm301039c
- Guidance literature:
-
Multi-step reaction with 7 steps
1: water / acetonitrile / 12 h / 40 °C
2: tetrahydrofuran / 1.5 h / 0 °C
3: acetic anhydride / 0.5 h / 20 - 90 °C
4: 0 °C
5: diphenyl phosphoryl azide; triethylamine / toluene / 12 h / 0 - 20 °C
6: toluene / 1 h / Reflux
7: hydrogenchloride / 1,4-dioxane / 14 h / 0 - 20 °C
With
hydrogenchloride; diphenyl phosphoryl azide; water; acetic anhydride; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
6: |Curtius Rearrangement;
DOI:10.1021/jm301039c
