1-(9,9-Dimethyl-9H-fluoren-2-yl)isoquinoline

Base Information

• Chemical Name: 1-(9,9-Dimethyl-9H-fluoren-2-yl)isoquinoline
• CAS No.: 435277-99-9
• Molecular Formula: C₂₄H₁₉N
• Molecular Weight: 321.422
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID90591336
• Nikkaji Number: J1.948.910H
• Wikidata: Q72470479
• Mol file: 435277-99-9.mol

Synonyms:1-(9,9-Dimethyl-9H-fluoren-2-yl)isoquinoline;435277-99-9;1-(9,9-DIMETHYLFLUOREN-2-YL)ISOQUINOLINE;1-(9,9-Dimethylfluuoren-2-yl)isoquinoline;1-(9,9-Dimethyl-9H-fluoren-2-yl)-isoquinoline;SCHEMBL2174684;DTXSID90591336;AKOS016014081;1-(9,9-dimethylfluorene-2-yl)isoquinoline;1-(9,9-dimethylfluorene-2-yl) isoquinoline;CS-0435203;1-(9,9-dimethyl-9h-fluoren-2-yl) isoquinoline

Chemical Property of 1-(9,9-Dimethyl-9H-fluoren-2-yl)isoquinoline

Chemical Property:

• Boiling Point: 500.2 °C at 760 mmHg
• Flash Point: 221.2 °C
• PSA: 12.89000
• Density: 1.15 g/cm³
• LogP: 6.20810
• Storage Temp.: 2-8°C
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 321.151749610
• Heavy Atom Count: 25
• Complexity: 483

Purity/Quality:

98% purity ^*data from raw suppliers

1-(9,9-dimethyl-9H-fluoren-2-yl)isoquinoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C2=CC=CC=C2C3=C1C=C(C=C3)C4=NC=CC5=CC=CC=C54)C

Technology Process of 1-(9,9-Dimethyl-9H-fluoren-2-yl)isoquinoline

There total 2 articles about 1-(9,9-Dimethyl-9H-fluoren-2-yl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-chloroisoquinoline (19493-44-8) + 9,9-dimethyl-9H-fluoren-2-yl-2-boronic acid (333432-28-3) → 1-(9,9-dimethyl-9H-fluoren-2-yl)isoquinoline (435277-99-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; Heating;

DOI:10.1021/ja034732d

Reference yield:

2-iodo-9,9-dimethyl-9H-fluorene (144981-85-1) → 1-(9,9-dimethyl-9H-fluoren-2-yl)isoquinoline (435277-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi; B(OCH₃)3 / hexane; tetrahydrofuran / -70 °C

1.2: 14 percent / acidic aq. solution

2.1: 54 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; Trimethyl borate; sodium carbonate; In tetrahydrofuran; ethanol; hexane; toluene; 2.1: Suzuki coupling;

DOI:10.1021/ja034732d

upstream raw materials:

1-chloroisoquinoline

9,9-dimethyl-9H-fluoren-2-yl-2-boronic acid

2-iodo-9,9-dimethyl-9H-fluorene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 435277-99-9 1-(9,9-Dimethylfluuoren-2-yl)isoquinoline

Send

Send

Metric Ton KG G Pound L ML

Send

Send