(2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine

Base Information

• Chemical Name: (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine
• CAS No.: 321524-83-8
• Molecular Formula: C₂₅H₂₃NO₄
• Molecular Weight: 401.462
• Mol file: 321524-83-8.mol

Synonyms:(2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine

Chemical Property of (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine

There total 1 articles about (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + threo-L-(2S,3R)-β-methylphenylalanine (25488-27-1,134235-83-9) → (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine (321524-83-8,1214028-21-3)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; for 3h;

DOI:10.3762/bjoc.10.302

Reference yield: 93.0%

C30H42F3N3O4 + (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine (321524-83-8,1214028-21-3) → dicyclopropylmethyl (5S,8R,11S,14S)-14-sec-butyl-1-(9H-fluoren-9-yl)-3,6,9,12-tetraoxo-5,11-bis[(R)-1-phenylethyl]-8-{[(1S,2R)-2-(trifluoromethyl)cyclopropyl]methyl}-2-oxa-4,7,10,13-tetraazapentadecan-15-oate

Guidance literature:

C₃₀H₄₂F₃N₃O₄; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 4 ℃; for 0.333333h;

(2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine; With 2,4,6-trimethyl-pyridine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.3762/bjoc.10.302

Reference yield: 88.0%

C30H44FN3O4 + (2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine (321524-83-8,1214028-21-3) → C55H65FN4O7

Guidance literature:

C₃₀H₄₄FN₃O₄; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 4 ℃; for 0.333333h;

(2S,3R)-N-(9-fluorenylmethoxycarbonyl)-β-methylphenylalanine; With 2,4,6-trimethyl-pyridine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.3762/bjoc.10.302

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

threo-L-(2S,3R)-β-methylphenylalanine

Downstream raw materials:

[5-sec-butyl-18,19-dimethyl-11-(2-nitro-cyclopropylmethyl)-4,7,10,13,16,20-hexaoxo-8,14-bis-(1-phenyl-ethyl)-2-propenyl-eicosahydro-3a,6,9,12,15,19-hexaaza-cyclopentacyclononadecen-17-yl]-carbamic acid 4-methyl-benzyl ester

C₅₇H₈₂N₁₀O₁₃Si

C₅₈H₇₆ClN₁₁O₁₄

(2S,3S)-2-{(2S,3R)-2-[(R)-2-((2S,3R)-2-Amino-3-phenyl-butyrylamino)-3-((1R,2R)-2-nitro-cyclopropyl)-propionylamino]-3-phenyl-butyrylamino}-3-methyl-pentanoic acid methoxymethyl ester