ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

Base Information

• Chemical Name: ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate
• CAS No.: 1040546-89-1
• Molecular Formula: C₁₇H₁₈ClFN₂O₄
• Molecular Weight: 368.792
• Mol file: 1040546-89-1.mol

Synonyms:ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

Chemical Property of ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

There total 1 articles about ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate (1040542-76-4) + 1-(bromomethyl)-4-chloro-2-fluorobenzene (71916-82-0) → ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate (1040546-89-1)

Guidance literature:

ethyl 5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.666667h;

1-(bromomethyl)-4-chloro-2-fluorobenzene; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 47.0%

ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate (1040546-89-1) + sodium glycinate (6000-44-8) → N-{[2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinyl]carbonyl}glycine (1040540-70-2)

Guidance literature:

ethyl 2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate; sodium glycinate; In ethanol; at 150 ℃; for 0.333333h; Microwave heating;

With hydrogenchloride; In ethanol; water;

upstream raw materials:

ethyl 5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinecarboxylate

1-(bromomethyl)-4-chloro-2-fluorobenzene

Downstream raw materials:

N-{[2-[(4-chloro-2-fluorophenyl)methyl]-5-hydroxy-6-(1-methylethyl)-3-oxo-2,3-dihydro-4-pyridazinyl]carbonyl}glycine