3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

Base Information

Chemical Name:3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide
CAS No.:1383854-52-1
Molecular Formula:C₄₀H₄₃N₅O₃Si
Molecular Weight:669.899
Hs Code.:

3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

Synonyms:3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

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Chemical Property of 3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

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Technology Process of 3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

There total 13 articles about 3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1383854-51-0
3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methylbenzoic acid

: 73930-39-9,95216-83-4
1-phenylcyclopropane-1-amine hydrochloride

: 1383854-52-1
3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1383854-52-1
3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h / 0 - 20 °C

1.2: 18 h / 20 °C

1.3: 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -40 °C

2.2: 0.33 h / 20 °C

2.3: 20 °C

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; water / 18 h / 90 °C / Inert atmosphere; microwave tube; sealed tube

4.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 24 h / 20 °C

4.2: pH 6

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; n-butyllithium; lithium hydroxide monohydrate; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1383854-52-1
3-(2-(4-methoxyphenyl)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)pyrazolo[1,5-a]pyridin-5-yl)-4-methyl-N-(1-phenylcyclopropyl)benzamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 18 h / 20 °C

2.1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 2 h / Reflux

3.1: trifluoroacetic anhydride / 1,2-dimethoxyethane / 0.67 h / 20 °C / Inert atmosphere

3.2: 6.5 h / 0 °C / Inert atmosphere

3.3: 16 h / 70 °C / Inert atmosphere

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere; sealed tube

5.1: cesium fluoride / dichlorobis(chlorodi-tert-butylphosphine) palladium(II) / N,N-dimethyl-formamide / 18 h / 90 °C

6.1: N-iodo-succinimide / dichloromethane; acetonitrile / 2 h / 20 °C

7.1: XPhos / dichloro bis(acetonitrile) palladium(II) / 1,4-dioxane / 2 h / 110 °C / microwave tube; Inert atmosphere; sealed tube

8.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; water / 18 h / 90 °C / Inert atmosphere; microwave tube; sealed tube

9.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 24 h / 20 °C

9.2: pH 6

10.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium phosphate; N-iodo-succinimide; lithium hydroxide monohydrate; hydroxylamine hydrochloride; potassium acetate; N-ethyl-N,N-diisopropylamine; cesium fluoride; HATU; trifluoroacetic anhydride; sodium hydroxide; lithium hexamethyldisilazane; XPhos; dichloro bis(acetonitrile) palladium(II); tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichlorobis(chlorodi-tert-butylphosphine) palladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;