N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

Base Information

Chemical Name:N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide
CAS No.:157974-00-0
Molecular Formula:C₂₁H₂₇N₃O₅
Molecular Weight:401.462
Hs Code.:

Synonyms:N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

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Technology Process of N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

There total 1 articles about N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 157974-00-0
N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

Guidance literature:: With dicyclohexyl-carbodiimide; In ethyl acetate; Ambient temperature;
DOI:10.1021/jm00037a005

Reference yield:

: 157974-00-0
N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

: 157974-01-1
benzyl (R)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 0.666667h;
DOI:10.1021/jm00037a005

Reference yield:

: 157974-00-0
N-Boc-β-benzyl-D-aspartyl-3,5-dimethylpyrazolide

: 157974-03-3
4(R)-(Boc-amino)-1-((S)-benzylcarbamoylmethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: LAH / tetrahydrofuran / 0.67 h / -78 °C

2: 1.) glacial acetic acid, 2.) NaCNBH₃ / 1.) EtOH, 10 min, 2.) EtOH, 70 min

3: 100 percent / H₂, glacial acetic acid / 10percent Pd/C / 3040 Torr / Ambient temperature

4: 1.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N-hydroxybenzotriazole hydrate, 2.) diisopropylethylamine / 1.) DMF, 30 min, 2.) DMF, 2 h

With lithium aluminium tetrahydride; hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00037a005