(S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol

Base Information

• Chemical Name: (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol
• CAS No.: 1523535-64-9
• Molecular Formula: C₁₈H₂₄N₂O
• Molecular Weight: 284.401
• Mol file: 1523535-64-9.mol

Synonyms:(S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol

Chemical Property of (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol

There total 4 articles about (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl ((S)-2-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-2-oxo-1-phenylethyl)carbamate (1523535-94-5) → (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol (1523535-64-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; water; at 0 ℃; for 12h; Inert atmosphere; Reflux;

DOI:10.5012/bkcs.2014.35.7.1989

Reference yield:

(S)-N-(benzyloxycarbonyl)phenylglycine (5491-18-9,17609-52-8,53990-33-3,60584-76-1) → (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol (1523535-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / -15 °C / Inert atmosphere

1.2: 16 h / -15 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere; Reflux

With 4-methyl-morpholine; lithium aluminium tetrahydride; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2013.11.027

Reference yield:

L-Phenylalaninol (3182-95-4) → (S)-2-(((S)-2-(methylamino)-2-phenylethyl)amino)-3-phenylpropan-1-ol (1523535-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / -15 °C / Inert atmosphere

1.2: 16 h / -15 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere; Reflux

With 4-methyl-morpholine; lithium aluminium tetrahydride; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2013.11.027

upstream raw materials:

(S)-N-(benzyloxycarbonyl)phenylglycine

L-Phenylalaninol

benzyl ((S)-2-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-2-oxo-1-phenylethyl)carbamate

Downstream raw materials:

(S)-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-5-phenyl-4,5-dihydro-1H-imidazol-3-ium chloride