3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid
CAS No.:106484-68-8
Molecular Formula:C₁₂H₁₅F₃N₂O₂
Molecular Weight:276.259
Hs Code.:
DSSTox Substance ID:DTXSID301151158

Synonyms:DTXSID301151158;3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid;106484-68-8

Suppliers and Price of 3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:276.10856221
Heavy Atom Count:19
Complexity:331

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(CNC1=C(C=C(C=C1)C(F)(F)F)N)C(=O)O

Technology Process of 3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid

There total 3 articles about 3-[[2-Amino-4-(trifluoromethyl)phenyl]amino]-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 106484-65-5
2,2-Dimethyl-3-(2-nitro-4-trifluoromethyl-phenylamino)-propionic acid

: 106484-68-8
3-(2-Amino-4-trifluoromethyl-phenylamino)-2,2-dimethyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 0.5h; under 740 Torr; Ambient temperature;

Reference yield:

: 19036-43-2
aminopivalic acid

: 106484-68-8
3-(2-Amino-4-trifluoromethyl-phenylamino)-2,2-dimethyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Et₃N / ethanol / 20 h / Heating

2: 93 percent / H₂ / 10percent Pd/C / ethanol / 0.5 h / 740 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol;

Reference yield:

: 121-17-5
2-chloro-3-nitro-5-trifluoromethylbenzene

: 106484-68-8
3-(2-Amino-4-trifluoromethyl-phenylamino)-2,2-dimethyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / Et₃N / ethanol / 20 h / Heating

2: 93 percent / H₂ / 10percent Pd/C / ethanol / 0.5 h / 740 Torr / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol;