N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine

Base Information

• Chemical Name: N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine
• CAS No.: 958878-65-4
• Molecular Formula: C₁₃H₁₁F₄NO₂
• Molecular Weight: 289.229
• Mol file: 958878-65-4.mol

Synonyms:N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine

Chemical Property of N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine

There total 2 articles about N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-benzyloxycarbonyl-3,3-difluoro-2-trifluoromethylpyrrolidine (958878-64-3) → N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine (958878-65-4)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

DOI:10.1021/jo070719q

Reference yield: 7.0%

N-benzyloxycarbonyl-3,3-difluoro-2-trifluoromethylpyrrolidine (958878-64-3) → N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine (958878-65-4) + N-benzyloxycarbonyl-3-fluoro-2-trifluoromethyl-4,5-dihydropyrrole

Guidance literature:

With lithium hexamethyldisilazane; In diethyl ether; at -78 ℃; for 0.166667h;

DOI:10.1021/jo070719q

Reference yield:

N-benzyloxycarbonyl-2-difluoromethylene-3,3-difluoropyrrolidine (958878-65-4) + Gly-OBz (1738-68-7) → C22H21N2F3O4

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1021/jo070719q

upstream raw materials:

N-benzyloxycarbonyl-3,3-difluoro-2-trifluoromethylpyrrolidine