(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester
CAS No.:178159-29-0
Molecular Formula:C₂₅H₂₇F₃O₅S
Molecular Weight:496.548
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

There total 1 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 157611-59-1
(1S,2R)-2-[(E)-1-Methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentanol

: 178159-29-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

Guidance literature:: With 0,2,4-dichlorophenyl-0-methylisopropylamidothiophosphate; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/0040-4020(96)00294-3

Reference yield:

: 178159-29-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-hydroxy-cyclopentyl ester

Guidance literature:: With hydrogenchloride; In acetone; at 25 ℃; for 0.5h;
DOI:10.1016/0040-4020(96)00294-3

Reference yield:

: 178159-29-0
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (1S,2R)-2-[(E)-1-methyl-2-((R)-toluene-4-sulfinyl)-vinyloxy]-cyclopentyl ester

: (1S,2R)-2-acetoxycyclopentyl (R)-α-methoxy-α-(trifluoromethyl)phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1N HCl / acetone / 0.5 h / 25 °C

2: pyridine / 10 h / 25 °C

With pyridine; hydrogenchloride; In acetone;
DOI:10.1016/0040-4020(96)00294-3