6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

Base Information

Chemical Name:6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole
CAS No.:1429919-74-3
Molecular Formula:C₂₆H₂₆N₄
Molecular Weight:394.519
Hs Code.:

Synonyms:6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

Chemical Property:

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Technology Process of 6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

There total 8 articles about 6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1629619-25-5
C₂₈H₂₇N₃O₂

: 109-76-2,54018-94-9
Trimethylenediamine

: 1429919-74-3
6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

Guidance literature:: With tetraphosphorus decasulfide; Sealed tube;
DOI:10.1016/j.bmcl.2014.05.094

Reference yield:

: 4-(4-bromostyryl)-3-nitrobenzonitrile

: 1429919-74-3
6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

Guidance literature:: Multi-step reaction with 4 steps

1: triethyl phosphite / 4 h / 120 °C / Reflux

2: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol; water / 6 h / 75 °C / Inert atmosphere

4: tetraphosphorus decasulfide / Sealed tube

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraphosphorus decasulfide; sodium carbonate; N-ethyl-N,N-diisopropylamine; triethyl phosphite; In tetrahydrofuran; ethanol; water; toluene; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2014.05.094

Reference yield:

: 1394076-84-6
2-(4-bromophenyl)indole-6-carbonitrile

: 1429919-74-3
6-(3,4,5,6-tetrahydropyrimidin-2-yl)-2-[4'-(dimethylamino)biphenyl-4-yl]indole

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 22 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol; water / 6 h / 75 °C / Inert atmosphere

3: tetraphosphorus decasulfide / Sealed tube

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraphosphorus decasulfide; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2014.05.094