9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

Base Information

Chemical Name:9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine
CAS No.:1200462-19-6
Molecular Formula:C₃₄H₅₃ClN₄O₆Si₂
Molecular Weight:705.442
Hs Code.:

Synonyms:9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

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Chemical Property of 9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

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Technology Process of 9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

There total 9 articles about 9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 93420-32-7
(R/S)-1-(2-nitrophenyl)-2-methyl-1-propanol

: 1201544-68-4
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-chloromethyl-7-deazapurine

: 1200462-19-6
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

Guidance literature:: at 105 ℃; for 1h; Inert atmosphere; Neat (no solvent);
DOI:10.1002/anie.201106516

Reference yield:

: 1200462-09-4
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2‘-deoxyribofuranosyl]-6-chloro-7-methoxycarbonyl-7-deazapurine

: 1200462-19-6
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran; methanol / 0.92 h / 20 °C / Reflux

2: dmap; p-toluenesulfonyl chloride / dichloromethane / 18 h / 20 °C

3: 1 h / 105 °C / Inert atmosphere; Neat (no solvent)

With dmap; lithium borohydride; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.201106516

Reference yield:

: 1200462-11-8
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2‘-deoxyribofuranosyl]-6-chloro-7-hydroxymethyl-7-deazapurine

: 1200462-19-6
9-[β-D-3‘,5‘-O-bis-(tert-butyldimethylsilyl)-2’-deoxyribofuranosyl]-6-chloro-7-[1-(2-nitrophenyl)-2-methylpropyloxy]methyl-7-deazapurine

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; p-toluenesulfonyl chloride / dichloromethane / 18 h / 20 °C

2: 1 h / 105 °C / Inert atmosphere; Neat (no solvent)

With dmap; p-toluenesulfonyl chloride; In dichloromethane;
DOI:10.1002/anie.201106516