[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Base Information

Chemical Name:[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
CAS No.:200337-40-2
Molecular Formula:C₄₂H₆₇N₃O₄
Molecular Weight:678.012
Hs Code.:

[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Synonyms:[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Suppliers and Price of [3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

There total 3 articles about [3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 177489-83-7
benzyl (3-azidopropyl)carbamate

: 200337-35-5
(3-Oxo-propyl)-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

: 200337-40-2
[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: benzyl (3-azidopropyl)carbamate; With trimethylphosphane; In tetrahydrofuran; at 20 ℃; for 0.5 - 1h;

(3-Oxo-propyl)-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester; In tetrahydrofuran; for 3 - 18h;

With sodium tetrahydroborate; In ethanol; diethylene glycol dimethyl ether; at 20 ℃; for 20 - 24h;

Reference yield:

: 7144-08-3
Cholesteryl chloroformate

: 200337-40-2
[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / CH₂Cl₂ / Ambient temperature

2: 1.) (COCl)2, DMSO, 2.) i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2.) -78 deg C to r.t.

3: 1.) Me₃P, MS 4A, 2.) NaBH₄ / 1.) THF, 2.) EtOH, diglyme

With sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trimethylphosphane; In dichloromethane;
DOI:10.1002/(SICI)1521-3765(199801)4:1<137::AID-CHEM137>3.0.CO;2-2

Reference yield:

: 200337-33-3
cholesterol-3-(carboxyaminopropan-3-ol)

: 200337-40-2
[3-(3-Benzyloxycarbonylamino-propylamino)-propyl]-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) (COCl)2, DMSO, 2.) i-Pr₂NEt / 1.) CH₂Cl₂, -78 deg C, 2.) -78 deg C to r.t.

2: 1.) Me₃P, MS 4A, 2.) NaBH₄ / 1.) THF, 2.) EtOH, diglyme

With sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trimethylphosphane;
DOI:10.1002/(SICI)1521-3765(199801)4:1<137::AID-CHEM137>3.0.CO;2-2