Technology Process of (S)-6-((R)-hydroxyphenylmethyl)morpholin-3-one
There total 7 articles about (S)-6-((R)-hydroxyphenylmethyl)morpholin-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
isopropyl alcohol;
at 20 ℃;
for 2h;
DOI:10.1021/jo701554h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride / methanol; water / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 7600.51 Torr
3: potassium carbonate / 1 h / 0 °C
4: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C
With
hydrogenchloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate;
In
methanol; water; tert-butyl alcohol;
DOI:10.1039/c7ob01283g
- Guidance literature:
-
Multi-step reaction with 5 steps
1: (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; copper(II) acetate monohydrate / 72 h / 20 °C
2: hydrogenchloride / methanol; water / 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 7600.51 Torr
4: potassium carbonate / 1 h / 0 °C
5: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C
With
hydrogenchloride; palladium 10% on activated carbon; (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; potassium tert-butylate; hydrogen; copper(II) acetate monohydrate; potassium carbonate;
In
methanol; water; tert-butyl alcohol;
1: |Henry Nitro Aldol Condensation;
DOI:10.1039/c7ob01283g
